Boron Neutron Capture Therapy (BNCT) and the Design of its 2.5MV Compact Accelerator

摘要: Boron Neutron Capture Therapy (BNCT) uses boron-containing drugs with strong affinity for cancer cells to accumulate in cancer cells, and uses highintensity proton beams produced by accelerators to target and irradiate cancer cells with high-flux neutrons, achieving the goal of treating tumors by producing nuclear reactions between boron (10B) and neutrons. It has the advantages of precision and efficiency, and can overcome the normal cell damage caused by conventional radiotherapy. This article will explain the technology of BNCT and its working principle, and briefly describe the relevant technologies and application status. The article also focuses on the development of BNCT technology based on DC high-voltage accelerator technology, proposes a compact BNCT device structure design with an acceleration voltage of 2.5MV, and introducesan power supply system for ion source power which is based on generator to achieve potential isolation. Through the design and development of the prototype and the simultaneous conduct of relevant experiments, certain achievements such as the integration testinghaves successfully achieved proton beam extraction and acceleration at a maximum voltage of 2.5 MV, and the hydrogen protons were accelerated to bombard a solidstate lithium target, resulting in neutron production, which can lay the foundation for the next step of clinical trials, large-scale industrial applications, and the development of advanced medical technology in China.