Design of BSA for BCNT Device Based on 10 MeV Proton Beam Generated by Accelerator and Evaluation of Clinical Dose

Abstract: The rapid development of accelerators has accelerated the clinical application of BNCT. The beam moderation and shaping assembly (BSA) in accelerator-based boron neutron capture therapy (AB-BNCT) device is crucial for the production of epithermal neutrons. Based on the 10 MeV proton beam generated by accelerator, the BSA was designed using the Monte Carlo simulation method, and the BSA design scheme was verified by the dose distribution of the epithermal neutron beam in the human head model. The results show that when the accelerator current intensity reaches 2.2 mA, the designed BSA meets the requirements of the IAEA for BNCT treatment beams. In the clinical dose estimation, the advantage depth can reach 11.2 cm, and the advantage ratio is 5. In addition, the tumor boron physical dose can reach 16 Gy within the treatment time when the normal tissue reaches the tolerance dose. The above results show that the BSA design scheme given for the 10 MeV proton beam is very reliable, and the BNCT device according to this scheme has good clinical treatment effect.