Study on preparation technology of 64Cu radionuclide target

摘要: Purpose: The target preparation technology of 64Cu radionuclides, the quality control scheme of isotope target thickness and the yield of 64Cu radionuclides were systematically studied. Methods: 1. Based on the nuclear reaction principle of beam interaction with matter, the nuclear reaction cross section ratio parameter and the nuclear reaction probability ratio parameter were proposed to evaluate the target thickness and isotope yield. 2. A detailed solid target irradiation design was put forward, the Bethe-Block formula was used to derive the calculation method of target thickness in detail, and the mass thickness of the target (mass surface density) was used to control the thickness of the target. 3. According to Faraday's first and second electrolytic laws, the electroplating device model was designed and the electroplating process was proposed. Results: 1. SRIM software was used to calculate the stopping power of different density targets in detail, and the energy was matched according to the theoretical formula 2. The nuclear reaction cross section ratio and the nuclear reaction probability ratio were calculated of 10.5MeV proton incident on 64Ni target and exiting target with different energies. The results of the two parameters are similar, however the nuclear reaction probability ratio is added with the stopping power parameter, the nuclear reaction probability ratio parameter is larger and has more evaluation significance. 3. SRIM software was used to calculate the thickness and mass thickness parameters of the proton exiting target with different densities and different energies. The results showed that the yield efficiency is 91.94% and the required target cost is only 66.39% when the proton exiting target energy is 5.5MeV versus 0MeV. 4. The electrochemical equivalent of Ni and electroplating time parameters were calculated according to Faraday's electrolysis law, and 64Ni target was electroplated on the gold target holder. The electroplated target was irradiated with 11MeV proton beam, 48.97μA, for 6 hours, and the radiation activity of 64Cu was 1.34Ci, and its half-life was consistent with the expected results. Conclusion: The target preparation technology and electroplating theory of 64Cu radionuclides were systematically studied. For expensive isotope targets, the nuclear reaction cross-section ratio and the nuclear reaction probability ratio were proposed to evaluate the thickness of the target. By this method, the isotope targets can be greatly saved without seriously affecting the yield. This paper has theoretical and practical guiding significance for the design and preparation of isotope targets.