Changes in urine proteins of unaffected individuals with a family history of frontotemporal dementia

Abstract: Frontotemporal dementia (FTD) is a very common type of neurodegenerative dementia and is the main cause of dementia in people under 65 years old. It has strong heritability. To explore whether there are urine proteins and biological pathways that are different between those who have not been identified with FTD under existing diagnostic methods and healthy people, this study conducts urinary proteomics analysis on people without disease with a family history of FTD and healthy people. The results show that there are 387 significantly different proteins (P<0.01; FC≥2.0 or ≤0.5) between the two groups. Among them, many proteins have been reported to play a role in FTD or the nervous system. In particular, Progranulin (PGRN) is considered an effective biomarker for FTD. Among the 139 biological pathways enriched by differential proteins (P<0.01), there are many pathways directly related to neurons and the nervous system, including glial cells and microglia. The differences in urinary proteomes between people without disease with a family history of FTD and healthy people make urinary proteomics have the potential to provide clues in exploring potential FTD patient populations and exploring the mechanisms related to the early occurrence and development of FTD, opening up a new perspective for FTD prevention and early diagnosis.