Poly[Lactic Acid] Hemodialysis Membranes with Poly[Lactic Acid]-block-Poly[2-Hydroxyethyl Methacrylate] Copolymer As Additive: Preparation, Characterization, and Performance 后印本

摘要: Poly(lactic acid) (PLA) hemodialysis membranes with enhanced antifouling capability and hemocompatibility were developed using poly(lactic acid)-block-poly(2-hydroxyethyl methacrylate) (PLA−PHEMA) copolymers as the blending additive. PLA−PHEMA block copolymers were synthesized via reversible addition−fragmentation (RAFT) polymerization from aminolyzed PLA. Gel permeation chromatography (GPC) and 1H-nuclear magnetic resonance (1H NMR) were applied to characterize the synthesized products. By blending PLA with the amphiphilic block copolymer, PLA/PLA−PHEMA membranes were prepared by nonsolvent induced phase separation (NIPS) method. Their chemistry and structure were characterized with X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM) and atomic force microscopy (AFM). The results revealed that PLA/PLA−PHEMA membranes with high PLA−PHEMA contents exhibited enhanced hydrophilicity, water permeability, antifouling and hemocompatibility. Especially, when the PLA−PHEMA concentration was 15 wt %, the water flux of the modified membrane was about 236 L m−2 h−1. Its urea and creatinine clearance was more than 0.70 mL/min, lysozyme clearance was about 0.50 mL/min, BSA clearance was as less as 0.31 mL/min. All the results suggest that PLA−PHEMA copolymers had served as effective agents for optimizing the property of PLA-based membrane for hemodialysis applications.